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Calculated risk: a new single-nucleotide polymorphism linked to severe influenza disease

Nature Medicine volume 23, pages 911912 (2017) | Download Citation

Clear links between human genes and susceptibility to influenza disease are scarce. A recent study uncovers a gene variant coupled to severe influenza, and shows how it hampers the expression of an antiviral gene that is key to immune cell survival.

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References

  1. 1.

    Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) Influenza. N. Engl. J. Med. 362, 17081719 (2010).

  2. 2.

    et al. Nat. Med. 23, 975–983 (2017).

  3. 3.

    , , & Annu. Rev. Virol. 1, 261–283 (2014).

  4. 4.

    et al. Nature 484, 519–523 (2012).

  5. 5.

    et al. Proc. Natl. Acad. Sci. USA 111, 769–774 (2014).

  6. 6.

    et al. Nat. Commun. 4, 1418 (2013).

  7. 7.

    et al. Eur. J. Clin. Microbiol. Infect. Dis. 35, 1811–1817 (2016).

  8. 8.

    et al. J. Infect. Dis. 209, 1028–1031 (2014).

  9. 9.

    , , & Influenza Other Respi. Viruses 7 Suppl 2, 37–41 (2013).

  10. 10.

    et al. PLoS One 10, e0139681 (2015).

  11. 11.

    et al. J. Infect. Dis. 206, 495–503 (2012).

  12. 12.

    et al. Eur. Respir. J. 39, 604–610 (2012).

Download references

Acknowledgements

This study was funded by the Leading Advanced Projects for medical innovation (LEAP) from the Japan Agency for Medical Research and Development (AMED); and grant U19AI106772 (to Y.K.), provided by the National Institute of Allergy and Infectious Diseases, US National Institutes of Health. The authors thank S. Watson for editing the manuscript.

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Affiliations

  1. Amie J. Eisfeld and Yoshihiro Kawaoka are in the Department of Pathobiological Sciences, University of Wisconsin–Madison, Madison, Wisconsin, USA.

    • Amie J Eisfeld
    •  & Yoshihiro Kawaoka
  2. Yoshihiro Kawaoka is additionally in the Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, and the International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

    • Yoshihiro Kawaoka

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Yoshihiro Kawaoka.

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DOI

https://doi.org/10.1038/nm.4383

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