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α5 nicotinic receptors link smoking to schizophrenia

Nature Medicine volume 23, pages 277278 (2017) | Download Citation

A new study shows that nicotinic receptors activate a particular type of interneuron in the prefrontal cortex. Deficits in this relationship give rise to behavioral abnormalities similar to those associated with schizophrenia, which can be ameliorated by nicotine.

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Author information

Affiliations

  1. Xin-an Liu and Paul J. Kenny are in the Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Xin-an Liu
    •  & Paul J Kenny

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Paul J Kenny.

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DOI

https://doi.org/10.1038/nm.4300

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