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Caspase-2 and tau—a toxic partnership?

Misfolded and hyperphosphorylated forms of the microtubule-associated protein tau are thought to be responsible for some degree of neurodegeneration. The demonstration of a novel toxic cleavage of tau by caspase-2 opens up new therapeutic avenues.

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Figure 1: Caspase-2 cleavage of tau.

Katie Vicari/Nature Publishing Group


  1. Weingarten, M.D., Lockwood, A.H., Hwo, S.Y. & Kirschner, M.W. Proc. Natl. Acad. Sci. USA 72, 1858–1862 (1975).

    Article  CAS  Google Scholar 

  2. Migheli, A., Butler, M., Brown, K. & Shelanski, M.L. J. Neurosci. 8, 1846–1851 (1988).

    Article  CAS  Google Scholar 

  3. Cleveland, D.W., Hwo, S.Y. & Kirschner, M.W. J. Mol. Biol. 116, 207–225 (1977).

    Article  CAS  Google Scholar 

  4. Goedert, M., Spillantini, M.G., Cairns, N.J. & Crowther, R.A. Neuron 8, 159–168 (1992).

    Article  CAS  Google Scholar 

  5. Terry, R.D. J. Neuropathol. Exp. Neurol. 22, 629–642 (1963).

    Article  CAS  Google Scholar 

  6. Kidd, M. Nature 197, 192–193 (1963).

    Article  CAS  Google Scholar 

  7. Spillantini, M.G. & Goedert, M. Trends Neurosci. 21, 428–433 (1998).

    Article  CAS  Google Scholar 

  8. Wang, Y., Garg, S., Mandelkow, E.-M. & Mandelkow, E. Biochem. Soc. Trans. 38, 955–961 (2010).

    Article  CAS  Google Scholar 

  9. Rissman, R.A. et al. J. Clin. Invest. 114, 121–130 (2004).

    Article  CAS  Google Scholar 

  10. Zhao, X. et al. Nat. Med. 22, 1268–1276, (2016).

    Article  CAS  Google Scholar 

  11. Troy, C.M. et al. J. Neurosci. 20, 1386–1392 (2000).

    Article  CAS  Google Scholar 

  12. Pozueta, J. et al. Nat. Commun. 1939, 4 (2013).

    Google Scholar 

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Correspondence to Michael L Shelanski.

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Troy, C., Shelanski, M. Caspase-2 and tau—a toxic partnership?. Nat Med 22, 1207–1208 (2016).

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