Misfolded and hyperphosphorylated forms of the microtubule-associated protein tau are thought to be responsible for some degree of neurodegeneration. The demonstration of a novel toxic cleavage of tau by caspase-2 opens up new therapeutic avenues.
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A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients
Acta Neuropathologica Communications Open Access 30 July 2019
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Troy, C., Shelanski, M. Caspase-2 and tau—a toxic partnership?. Nat Med 22, 1207–1208 (2016). https://doi.org/10.1038/nm.4227
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DOI: https://doi.org/10.1038/nm.4227
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A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients
Acta Neuropathologica Communications (2019)