A recent study suggests that exposure to the mold Aspergillus induces the production of antibodies that neutralize interferon-γ (IFN-γ), which increases the risk of mycobacterial disease.
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Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study
Journal of Clinical Immunology Open Access 15 January 2020
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Acknowledgements
This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, NIH.
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Notarangelo, L., Holland, S. Friendly fire: anti-cytokine antibodies elicited by microbes. Nat Med 22, 973–975 (2016). https://doi.org/10.1038/nm.4175
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DOI: https://doi.org/10.1038/nm.4175
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Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study
Journal of Clinical Immunology (2020)