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HIV-1 immune evasion—a threat to effective vaccines?

Nature Medicine volume 22, pages 580581 (2016) | Download Citation

A new study of the impact of cytotoxic T lymphocyte (CTL) escape mutations suggests that holes in the host immune repertoire contribute to poor disease outcomes, owing to a gradual deterioration of the host anti-HIV-1 immune response. This should be accounted for in HIV-1 vaccine development strategies.

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Acknowledgements

M.R. thanks A. Manrique, N. Michael, J. Mullins, L. Reilly and M. Robb for their comments.

Author information

Affiliations

  1. Morgane Rolland is in the US Military HIV Research Program, WRAIR, Silver Spring, Maryland, USA, and at the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.

    • Morgane Rolland

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Morgane Rolland.

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DOI

https://doi.org/10.1038/nm.4119

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