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Closing the loop on the bone-resorbing osteoclast

A new study shows in mice that tumor necrosis factor (TNF) superfamily member 11 (TNFSF11, also known as RANKL), which stimulates osteoclasts to remove bone, binds to the G-protein-coupled receptor LGR4 to prevent excessive bone removal. In mouse models of osteoporosis, a recombinant LGR4 ectodomain reduces bone loss.

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Figure 1: The osteoclast negative-feedback loop.

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Correspondence to Mone Zaidi.

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Competing interests

Mone Zaidi has consulted and/or consults for Merck, Novartis, Roche, Alexion, Gershon Lehman Group and Guidepoint on issues related to osteoporosis and its treatment. A patent relating to the effects of follicle-stimulating hormone on bone has been granted, and any proceeds to the Icahn School of Medicine at Mount Sinai from licensing or royalty will be shared with Dr. Zaidi.

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Zaidi, M., Iqbal, J. Closing the loop on the bone-resorbing osteoclast. Nat Med 22, 460–461 (2016). https://doi.org/10.1038/nm.4104

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