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Cardiotoxicity in a dish: new insights for personalized therapy

Nature Medicine volume 22, pages 459–460 (2016)Cite this article

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A recent study identifies differences in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes from patients with breast cancer who were treated with doxorubicin and either did or did not develop cardiotoxicity. The results open up new avenues for the development of personalized therapy and the prevention of cardiotoxicity.

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Figure 1: Cardiac hiPSCs can give indications as to the cardiotoxicity of doxorubicin.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Mitch Biermann and Timothy J. Kamp are in the Departments of Medicine and Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin, USA, and the Stem Cell and Regenerative Medicine Center, University of Wisconsin–Madison, Madison, Wisconsin, USA.,

    Mitch Biermann & Timothy J Kamp

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  1. Mitch Biermann
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  2. Timothy J Kamp
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Correspondence to Timothy J Kamp.

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Competing interests

T.J.K. is a consultant for Cellular Dynamics International.

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Biermann, M., Kamp, T. Cardiotoxicity in a dish: new insights for personalized therapy. Nat Med 22, 459–460 (2016). https://doi.org/10.1038/nm.4095

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