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The cellular origins of drug resistance in cancer

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Two new studies show that mechanisms of acquired resistance to targeted therapy in lung cancer do not necessarily pre-exist in resistant subclones. Instead, some cancers may harbor the potential to acquire a variety of drug-resistance mechanisms after response to targeted therapy.

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Figure 1: Differing biologies of acquired drug resistance.

Marina Corral Spence/Nature Publishing Group

References

  1. Hata, A.N. et al. Nat. Med. 22, 262–269 (2016).

    Article  CAS  Google Scholar 

  2. Ramirez, M. et al. Nat. Commun. 7, 10.1038/ncomms10690 (19 February 2016).

  3. Arcila, M.E. et al. Clin. Cancer Res. 17, 1169–1180 (2011).

    Article  CAS  Google Scholar 

  4. Zhou, W. et al. Nature 462, 1070–1074 (2009).

    Article  CAS  Google Scholar 

  5. Chmielecki, J. et al. Sci. Transl. Med. 3, 90ra59 (2011).

    Article  CAS  Google Scholar 

  6. Jänne, P.A. et al. N. Engl. J. Med. 372, 1689–1699 (2015).

    Article  Google Scholar 

  7. Ye, X., et al. J. Thorac. Oncol. 8, 1118–1120 (2013).

    Article  Google Scholar 

  8. Sharma, S.V. et al. Cell 141, 69–80 (2010).

    Article  CAS  Google Scholar 

  9. Engelman, J.A. et al. Science 316, 1039–1043 (2007).

    Article  CAS  Google Scholar 

  10. Tricker, E.M. et al. Cancer Discov. 5, 960–971 (2015).

    Article  CAS  Google Scholar 

  11. Oxnard, G.R. et al. Clin. Cancer Res. 20, 1698–1705 (2014).

    Article  CAS  Google Scholar 

  12. Thress, K.S. et al. Nat. Med. 21, 560–562 (2015).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Geoffrey R Oxnard.

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Competing interests

G.R.O. has received consulting fees from Ariad, AstraZeneca, Boehringer-Ingehleim, Clovis and Genentech.

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Oxnard, G. The cellular origins of drug resistance in cancer. Nat Med 22, 232–234 (2016). https://doi.org/10.1038/nm.4058

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