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Depleting senescent cells to combat aging

Nature Medicine volume 22, pages 2324 (2016) | Download Citation

A new study in mice suggests that pharmacologically targeting the apoptosis proteins BCL-2 and BCL-xL can clear senescent cells from bone marrow and ameliorate stem cell function during aging, bringing us a step closer to preventing senescence-associated tissue attrition in the clinic.

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Author information

Affiliations

  1. Hartmut Geiger is at the Institute for Molecular Medicine and Aging Research Center Ulm, University of Ulm, Ulm, Germany, and in the Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

    • Hartmut Geiger

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Hartmut Geiger.

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DOI

https://doi.org/10.1038/nm.4024

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