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Up-front polytherapy for ALK-positive lung cancer

A new study identifies the RAS-MAPK pathway to be an Achilles' heel of EML4-ALK fusion-positive lung cancer and suggests that up-front combination therapy directed against both pathways can achieve sustained suppression of tumor growth.

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Figure 1: Up-front concurrent inhibition of ALK and MEK leads to sustained tumor growth suppression in EML4-ALK–positive lung cancer.

Marina Corral Spence/Nature Publishing Group


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Correspondence to Adrienne D Cox.

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Zhou, B., Cox, A. Up-front polytherapy for ALK-positive lung cancer. Nat Med 21, 974–975 (2015).

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