Notch signaling maintains T cell memories

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Notch signaling regulates developmental processes. A new study in mice shows that Notch signaling regulates the maintenance and survival of memory CD4+ T lymphocytes through a mechanism involving glucose uptake, and it suggests that Notch signaling can be modulated to treat autoimmune conditions.

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Figure 1: Notch signaling is required for maintenance of memory CD4+ T cells.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Stephen P Schoenberger.

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The authors declare no competing financial interests.

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Miller, A., Schoenberger, S. Notch signaling maintains T cell memories. Nat Med 21, 16–18 (2015) doi:10.1038/nm.3784

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