Notch signaling regulates developmental processes. A new study in mice shows that Notch signaling regulates the maintenance and survival of memory CD4+ T lymphocytes through a mechanism involving glucose uptake, and it suggests that Notch signaling can be modulated to treat autoimmune conditions.
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References
Zhu, J., Yamane, H. & Paul, W.E. Annu. Rev. Immunol. 28, 445–489 (2010).
Mueller, S.N., Gebhardt, T., Carbone, F.R. & Heath, W.R. Annu. Rev. Immunol. 31, 137–161 (2013).
Devarajan, P. & Chen, Z. Immunol. Res. 57, 12–22 (2013).
Ciofani, M. & Zuniga-Pflucker, J.C. Nat. Immunol. 6, 881–888 (2005).
Helbig, C. et al. Proc. Natl. Acad. Sci. USA 109, 9041–9046 (2012).
Andersson, E.R., Sandberg, R. & Lendahl, U. Development 138, 3593–3612 (2011).
Artavanis-Tsakonas, S., Rand, M.D. & Lake, R.J. Science 284, 770–776 (1999).
Maekawa, Y. et al. Nat. Med. 21, 55–61 (2015).
Backer, R.A. et al. Nat. Immunol. 15, 1143–1151 (2014).
Pearce, E.L., Poffenberger, M.C., Chang, C.H. & Jones, R.G. Science 342, 1242454 (2013).
O'Sullivan, D. et al. Immunity 41, 75–88 (2014).
Andersson, E.R. & Lendahl, U. Nat. Rev. Drug Discov. 13, 357–378 (2014).
Tolcher, A.W. et al. J. Clin. Oncol. 30, 2348–2353 (2012).
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Miller, A., Schoenberger, S. Notch signaling maintains T cell memories. Nat Med 21, 16–18 (2015). https://doi.org/10.1038/nm.3784
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DOI: https://doi.org/10.1038/nm.3784