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Antiangiogenic VEGF-A in peripheral artery disease

Vascular endothelial growth factor A (VEGF-A) is a potent proangiogenic cytokine elevated in patients with peripheral artery disease (PAD). A new study links impaired vascular regrowth in PAD to increased expression of an antiangiogenic splice variant of VEGF-A.

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Figure 1: Patients with PAD have decreased blood flow in leg arteries resulting from atherosclerotic plaques.

Katie Vicari/Nature Publishing Group

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Correspondence to Victoria L Bautch.

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Boucher, J., Bautch, V. Antiangiogenic VEGF-A in peripheral artery disease. Nat Med 20, 1383–1385 (2014). https://doi.org/10.1038/nm.3767

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