Vascular endothelial growth factor A (VEGF-A) is a potent proangiogenic cytokine elevated in patients with peripheral artery disease (PAD). A new study links impaired vascular regrowth in PAD to increased expression of an antiangiogenic splice variant of VEGF-A.
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VEGF-A splice variants bind VEGFRs with differential affinities
Scientific Reports Open Access 02 September 2020
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References
Annex, B.H. Nat. Rev. Cardiol. 10, 387–396 (2013).
Kikuchi, R. et al. Nat. Med. 20, 1464–1471 (2014).
Shimamura, M., Nakagami, H., Koriyama, H. & Morishita, R. Biomed. Res. Int. 2013, 186215 (2013).
Makin, A.J., Chung, N.A.Y., Silverman, S.H. & Lip, G.Y.H. Clin. Sci. 104, 397–404 (2003).
Bates, D.O. et al. Cancer Res. 62, 4123–4131 (2002).
Peiris-Pagès, M. Cell Adh. Migr. 6, 561–568 (2012).
Volpi, N. et al. Mediators Inflamm. 2013, 219313 (2013).
Jones, W.S. et al. Vasc. Med. 17, 94–100 (2012).
Kikuchi, A., Yamamoto, H., Sato, A. & Matsumoto, S. Acta Physiol. (Oxf.) 204, 17–33 (2012).
Stefater, J.A. III et al. Nature 474, 511–515 (2011).
Ouchi, N. et al. Science 329, 454–457 (2010).
Merdzhanova, G. et al. Oncogene 29, 5392–5403 (2010).
Rieder, D. et al. Cell. Mol. Life Sci. 71, 1741–1759 (2014).
Yoshida, K. et al. Nature 478, 64–69 (2011).
Nowak, D.G. et al. J. Cell Sci. 121, 3487–3495 (2008).
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Boucher, J., Bautch, V. Antiangiogenic VEGF-A in peripheral artery disease. Nat Med 20, 1383–1385 (2014). https://doi.org/10.1038/nm.3767
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DOI: https://doi.org/10.1038/nm.3767
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