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Understanding the role of progranulin in Alzheimer's disease

Alzheimer's disease is characterized by severe cognitive decline and brain amyloid plaques. A new study in mouse models that develop features of Alzheimer's disease indicates that progranulin may have a role in clearing these plaques.

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Figure 1: The role of progranulin in amyloid plaque formation.

Katie Vicari/Nature Publishing Group

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Correspondence to Jada Lewis.

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D'Alton, S., Lewis, J. Understanding the role of progranulin in Alzheimer's disease. Nat Med 20, 1099–1100 (2014). https://doi.org/10.1038/nm.3712

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