Alzheimer's disease is characterized by severe cognitive decline and brain amyloid plaques. A new study in mouse models that develop features of Alzheimer's disease indicates that progranulin may have a role in clearing these plaques.
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References
Fargo, K. & Bleiler, L. Alzheimers Dement. 10, e47–e92 (2014).
Schneider, L.S. et al. J. Intern. Med. 275, 251–283 (2014).
Baker, M. et al. Nature 442, 916–919 (2006).
Cruts, M. et al. Nature 442, 920–924 (2006).
Petkau, T.L. & Leavitt, B.R. Trends Neurosci. 37, 388–398 (2014).
Sheng, J., Su, L., Xu, Z. & Chen, G. Gene 542, 141–145 (2014).
Minami, S.S. et al. Nat. Med. 20, 1157–1164 (2014).
Pereson, S. et al. J. Pathol. 219, 173–181 (2009).
Lucin, K.M. et al. Neuron 79, 873–886 (2013).
Kim, W.S. et al. J. Neurosci. 33, 4387–4394 (2013).
Karch, C.M. & Goate, A.M. Biol. Psychiatry. doi:10.1016/j.biopsych.2014.05.006 (17 May 2014).
Boxer, A.L. et al. Alzheimers Dement. 9, 176–188 (2013).
Toh, H., Chitramuthu, B.P., Bennett, H.P. & Bateman, A. J. Mol. Neurosci. 45, 538–548 (2011).
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D'Alton, S., Lewis, J. Understanding the role of progranulin in Alzheimer's disease. Nat Med 20, 1099–1100 (2014). https://doi.org/10.1038/nm.3712
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DOI: https://doi.org/10.1038/nm.3712