Inhibiting Janus kinases to treat alopecia areata

Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Positive feedback loop in AA.

Debbie Maizels/Nature Publishing Group

References

  1. 1

    Gilhar, A., Etzioni, A. & Paus, R. N. Engl. J. Med. 366, 1515–1525 (2012).

  2. 2

    Xing, L. et al. Nat. Med. 20, 1043–1049 (2014).

  3. 3

    Sundberg, J.P., Cordy, W.R. & King, L.E. Jr. J. Invest. Dermatol. 102, 847–856 (1994).

  4. 4

    McElwee, K.J., Boggess, D., King, L.E. Jr. & Sundberg, J.P. J. Invest. Dermatol. 111, 797–803 (1998).

  5. 5

    Sundberg, J.P., Silva, K.A., Li, R., Cox, G.A. & King, L.E. J. Invest. Dermatol. 123, 294–297 (2004).

  6. 6

    McElwee, K.J. et al. Pathobiology 66, 90–107 (1998).

  7. 7

    Petukhova, L. et al. Nature 466, 113–117 (2010).

  8. 8

    Gilhar, A., Kam, Y., Assy, B. & Kalish, R.S. J. Invest. Dermatol. 124, 288–289 (2005).

  9. 9

    Freyschmidt-Paul, P. et al. Br. J. Dermatol. 155, 515–521 (2006).

  10. 10

    Brajac, I., Gruber, F., Petrovecki, M. & Malnar-Dragojevic, D. Acta Dermatovenerol. Croat. 12, 154–156 (2004).

  11. 11

    Weng, N.P., Liu, K., Catalfamo, M., Li, Y. & Henkart, P.A. Ann. NY Acad. Sci. 975, 46–56 (2002).

  12. 12

    Spolski, R. & Leonard, W.J. Nat. Rev. Drug Discov. 13, 379–395 (2014).

  13. 13

    Craiglow, B.G. & King, B.A. J. Invest. Dermatol. doi:10.1038/jid.2014.260 (17 July 2014).

  14. 14

    Quintás-Cardama, A. et al. Blood 115, 3109–3117 (2010).

  15. 15

    Ghoreschi, K. et al. J. Immunol. 186, 4234–4243 (2011).

  16. 16

    Andersson, A.K. et al. Arthritis Rheum. 63, 2617–2629 (2011).

Download references

Author information

Correspondence to Thomas S Kupper.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Divito, S., Kupper, T. Inhibiting Janus kinases to treat alopecia areata. Nat Med 20, 989–990 (2014) doi:10.1038/nm.3685

Download citation

Further reading