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Interleukin-35 takes the 'B' line

Nature Medicine volume 20, pages 580–581 (2014)Cite this article

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Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell–derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease.

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Figure 1: The immunosuppressive cytokine IL-35 induces the expansion of Breg cells, which secrete IL-35 to protect from autoimmune disease.

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  1. Division of Medicine, Claudia Mauri and Kiran Nistala are at the Centre for Rheumatology, University College London, London, UK.,

    Claudia Mauri & Kiran Nistala

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  1. Claudia Mauri
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  2. Kiran Nistala
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Correspondence to Claudia Mauri or Kiran Nistala.

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Mauri, C., Nistala, K. Interleukin-35 takes the 'B' line. Nat Med 20, 580–581 (2014). https://doi.org/10.1038/nm.3594

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