Engaging a senescent response to cure leukemia

Retinoic acid and arsenic trioxide cure individuals with acute promyelocytic leukemia (APL). In mouse models, these drugs eradicate tumor cells by activating the tumor suppressors p53 and PML to induce senescence of cancer cells (pages 167–174).

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Figure 1: A senescence mechanism for the antileukemia effect of RA and arsenic.

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Correspondence to Gerardo Ferbeyre.

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Bourdeau, V., Ferbeyre, G. Engaging a senescent response to cure leukemia. Nat Med 20, 123–124 (2014). https://doi.org/10.1038/nm.3469

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