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Engaging a senescent response to cure leukemia

Nature Medicine volume 20, pages 123–124 (2014)Cite this article

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Retinoic acid and arsenic trioxide cure individuals with acute promyelocytic leukemia (APL). In mouse models, these drugs eradicate tumor cells by activating the tumor suppressors p53 and PML to induce senescence of cancer cells (pages 167–174).

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Figure 1: A senescence mechanism for the antileukemia effect of RA and arsenic.

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Authors and Affiliations

  1. Véronique Bourdeau and Gerardo Ferbeyre are at the Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Québec, Canada.,

    Véronique Bourdeau & Gerardo Ferbeyre

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  1. Véronique Bourdeau
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  2. Gerardo Ferbeyre
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Correspondence to Gerardo Ferbeyre.

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The authors declare no competing financial interests.

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Bourdeau, V., Ferbeyre, G. Engaging a senescent response to cure leukemia. Nat Med 20, 123–124 (2014). https://doi.org/10.1038/nm.3469

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