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Hepatocytes break the silence during liver-stage malaria

Liver-stage Plasmodium infection triggers a type I interferon transcriptional program in hepatocytes that amplifies an innate immune response within hepatic myeloid cells. This minimizes liver parasite load and delays the release of disease-causing parasites into the bloodstream (pages 47–53).

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Figure 1: Sensing malaria parasites in the liver.

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Correspondence to Christian Engwerda.

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Haque, A., Engwerda, C. Hepatocytes break the silence during liver-stage malaria. Nat Med 20, 17–19 (2014). https://doi.org/10.1038/nm.3446

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