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Akt2 relaxes podocytes in chronic kidney disease

A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).

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Figure 1: Podocyte function under conditions of nephron reduction.

Marina Corral Spence

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Correspondence to Jochen Reiser.

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Competing interests

J.R. is an inventor on issued and pending patents on new mechanisms and technologies for proteinuric kidney diseases. He stands to gain royalties from the commercialization of these technologies.

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Reiser, J. Akt2 relaxes podocytes in chronic kidney disease. Nat Med 19, 1212–1213 (2013). https://doi.org/10.1038/nm.3357

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