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Proliferating macrophages prevail in atherosclerosis

Nature Medicine volume 19, pages 1094–1095 (2013)Cite this article

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Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes (pages 1166–1172).

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Figure 1: An integrated model of the mechanisms of macrophage accumulation within established atherosclerotic plaques.

Marina Corral Spence

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  1. Gwendalyn J. Randolph is in the Department of Pathology and Immunology at Washington University School of Medicine, St. Louis, Missouri, USA.,

    Gwendalyn J Randolph

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  1. Gwendalyn J Randolph
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Correspondence to Gwendalyn J Randolph.

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Randolph, G. Proliferating macrophages prevail in atherosclerosis. Nat Med 19, 1094–1095 (2013). https://doi.org/10.1038/nm.3316

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