Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes (pages 1166–1172).
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Randolph, G. Proliferating macrophages prevail in atherosclerosis. Nat Med 19, 1094–1095 (2013). https://doi.org/10.1038/nm.3316
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DOI: https://doi.org/10.1038/nm.3316
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