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TGF-β and osteoarthritis—the good and the bad


Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).

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Figure 1: TGF-β affects multiple joint tissues.

Katie Vicari


  1. Berenbaum, F. Osteoarthritis Cartilage 21, 16–21 (2013).

    Article  CAS  Google Scholar 

  2. Felson, D.T. Osteoarthritis Cartilage 21, 10–15 (2013).

    Article  CAS  Google Scholar 

  3. Goldring, M.B. & Goldring, S.R. Ann. NY Acad. Sci. 1192, 230–237 (2010).

    Article  CAS  Google Scholar 

  4. Zhen, G. et al. Nat. Med. 19, 704–712 (2013).

    Article  CAS  Google Scholar 

  5. Janssens, K. et al. J. Med. Genet. 43, 1–11 (2006).

    Article  CAS  Google Scholar 

  6. Felson, D.T. et al. Ann. Intern. Med. 134, 541–549 (2001).

    Article  CAS  Google Scholar 

  7. Tang, Y. et al. Nat. Med. 15, 757–765 (2009).

    Article  CAS  Google Scholar 

  8. Burr, D.B. & Gallant, M.A. Nat. Rev. Rheumatol. 8, 665–673 (2012).

    Article  CAS  Google Scholar 

  9. Whyte, M.P. et al. J. Bone Miner. Res. 26, 920–933 (2011).

    Article  CAS  Google Scholar 

  10. Serra, R. et al. J. Cell Biol. 139, 541–552 (1997).

    Article  CAS  Google Scholar 

  11. Yang, X. et al. J. Cell Biol. 153, 35–46 (2001).

    Article  CAS  Google Scholar 

  12. Blaney Davidson, E.N., van der Kraan, P.M. & van den Berg, W.B. Osteoarthritis Cartilage 15, 597–604 (2007).

    Article  CAS  Google Scholar 

  13. van der Kraan, P.M. et al. Cell Tissue Res. 347, 257–265 (2012).

    Article  CAS  Google Scholar 

  14. van Beuningen, H.M. et al. Lab. Invest. 71, 279–290 (1994).

    CAS  PubMed  Google Scholar 

  15. Scharstuhl, A. et al. Arthritis Rheum. 48, 3442–3451 (2003).

    Article  CAS  Google Scholar 

  16. Pitsillides, A.A. & Beier, F. Nat. Rev. Rheumatol. 7, 654–663 (2011).

    Article  CAS  Google Scholar 

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Correspondence to Frank Beier.

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Bush, J., Beier, F. TGF-β and osteoarthritis—the good and the bad. Nat Med 19, 667–669 (2013).

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