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Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer

The RAS-RAF-MEK-ERK signaling kinase pathway has been the focus of intense cancer drug development efforts because of its central role in tumor cell proliferation and survival. Although inhibitors of RAF and MEK provide therapeutic validation, tumor resistance challenges their effectiveness. Targeting scaffolding proteins such as IQGAP1 may be a new approach (pages 626–630).

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Figure 1: The level of IQGAP1 expression is crucial for maintaining oncogenic phospho-ERK signaling.

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Correspondence to Darrin D Stuart.

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Stuart, D., Sellers, W. Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer. Nat Med 19, 538–540 (2013).

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