It has long been unknown how activation of resident macrophages in the brain, or microglia, is regulated during the inflammatory pathogenesis of multiple sclerosis. Work in a mouse model of human multiple sclerosis identifies the E3 ubiquitin ligase Peli1 as a new crucial regulator of microglia activation (pages 595–602).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
Journal of Neuroinflammation Open Access 04 November 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Compston, A. & Coles, A. Lancet 372, 1502–1517 (2008).
Benveniste, E.N. J. Mol. Med. 75, 165–173 (1997).
Xiao, Y. et al. Nat. Med. 19, 595–602 (2013).
Prinz, M. et al. J. Clin. Invest. 116, 456–464 (2006).
Jin, W., Chang, M. & Sun, S.C. Cell Mol. Immunol. 9, 113–122 (2012).
Moynagh, P.N. Trends Immunol. 30, 33–42 (2009).
Smith, H. et al. Biochem. J. 434, 537–548 (2011).
Chang, M. et al. Nat. Immunol. 12, 1002–1009 (2011).
Cusson-Hermance, N., Khurana, S., Lee, T.H., Fitzgerald, K.A. & Kelliher, M.A. J. Biol. Chem. 280, 36560–36566 (2005).
Tseng, P.H. et al. Nat. Immunol. 11, 70–75 (2010).
Zhu, S. et al. J. Exp. Med. 207, 2647–2662 (2010).
Eisele, S. et al. Brain Pathol. 22, 607–618 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Song, X., Qian, Y. Peli1 sets the CNS on fire. Nat Med 19, 536–538 (2013). https://doi.org/10.1038/nm.3176
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3176
This article is cited by
-
N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
Journal of Neuroinflammation (2016)