Heat from calcium cycling melts fat

A new study in mice shows that sarcolipin, a small, regulatory protein of the intracellular calcium pump (SERCA) in skeletal muscle, is part of a nonshivering thermogenic mechanism for regulating both core body temperature and energy balance (pages 1575–1579).

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Figure 1: Nonshivering thermogenesis (NST) from muscle and brown adipose tissue (BAT).

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Correspondence to Leslie P Kozak.

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Kozak, L., Young, M. Heat from calcium cycling melts fat. Nat Med 18, 1458–1459 (2012). https://doi.org/10.1038/nm.2956

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