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LIF-ting Hippo averts metastasis

Nature Medicine volume 18, pages 1463–1465 (2012)Cite this article

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Reactivation of 'metastasis suppressor' genes holds great promise for the treatment of incurable malignancies. To date, only a few of these genes have been identified. A new study shows that breast cancer metastasis can be blunted by leukemia inhibitory factor (LIF) signaling through regulation of the Hippo pathway, linking metastatic growth to the regulation of a pathway involved in building organs during development (pages 1511–1517).

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Figure 1: LIFR is an upstream regulator of the Hippo pathway.

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  1. Stefano Piccolo is in the Department of Biomedical Sciences, University of Padua School of Medicine, Padua, Italy.,

    Stefano Piccolo

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  1. Stefano Piccolo
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Correspondence to Stefano Piccolo.

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Piccolo, S. LIF-ting Hippo averts metastasis. Nat Med 18, 1463–1465 (2012). https://doi.org/10.1038/nm.2955

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