Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The dark side of the oxidative force in angiogenesis

A new mechanism regulating pathological angiogenesis has been identified that involves the activation of ataxia-telangiectasia mutated (Atm) kinase in response to reactive oxygen species. Importantly, this Atm-dependent pathway is specifically activated in pathological, but not in normal, angiogenesis, suggesting that it could be therapeutically targeted in diseases associated with pathological angiogenesis (pages 1208–1216).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Under oxidative stress, activated ATM induces angiogenesis.

Katie Vicari

References

  1. Ebos, J.M. & Kerbel, R.S. Nat. Rev. Clin. Oncol. 8, 210–221 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Guo, Z., Kozlov, S., Lavin, M.F., Person, M.D. & Paull, T.T. Science 330, 517–521 (2010).

    Article  CAS  PubMed  Google Scholar 

  3. Lavin, M.F. Nat. Rev. Mol. Cell Biol. 9, 759–769 (2008).

    Article  CAS  PubMed  Google Scholar 

  4. Meyn, M.S. Cancer Res. 55, 5991–6001 (1995).

    CAS  PubMed  Google Scholar 

  5. Barzilai, A., Rotman, G. & Shiloh, Y. DNA Repair (Amst.) 1, 3–25 (2002).

    Article  CAS  Google Scholar 

  6. Reichenbach, J. et al. Clin. Exp. Immunol. 117, 535–539 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Barlow, C. et al. Proc. Natl. Acad. Sci. USA 96, 9915–9919 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Perry, J.J. & Tainer, J.A. Sci. Signal. 4, pe18 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ito, K. et al. J. Immunol. 178, 103–110 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y. Nat. Med. 18, 1208–1216 (2012).

    Article  CAS  PubMed  Google Scholar 

  11. Ditch, S. & Paull, T.T. Trends Biochem. Sci. 37, 15 (2012).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tatiana V Byzova.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kerr, B., Byzova, T. The dark side of the oxidative force in angiogenesis. Nat Med 18, 1184–1185 (2012). https://doi.org/10.1038/nm.2881

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2881

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing