How blood-borne inflammatory cells cause tissue damage in the brain after ischemic stroke remains elusive. Peroxiredoxins, cytosolic antioxidant proteins vital for redox balance, are released extracellularly from ischemic cells, acting as potent 'danger signals' that activate macrophages and lead to a harmful cytokine response, a new study shows. The findings unveil a new culprit in the delayed phase of ischemic injury and suggest new therapeutic approaches (pages 911–917).
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References
Moskowitz, M.A., Lo, E.H. & Iadecola, C. Neuron 67, 181–198 (2010).
Iadecola, C. & Anrather, J. Nat. Med. 17, 796–808 (2011).
Shichita, T. et al. Nat. Med. 18, 911–917 (2012).
Kunz, A. et al. J. Neurosci. 28, 1649–1658 (2008).
Tang, S.C. et al. Proc. Natl. Acad. Sci. USA 104, 13798–13803 (2007).
Chen, G.Y. & Nunez, G. Nat. Rev. Immunol. 10, 826–837 (2010).
Shichita, T. et al. Nat. Med. 15, 946–950 (2009).
Zhu, H., Santo, A. & Li, Y. Exp. Biol. Med. (Maywood) 237, 143–149 (2012).
Riddell, J.R., Wang, X.Y., Minderman, H. & Gollnick, S.O. J. Immunol. 184, 1022–1030 (2010).
Hayakawa, K., Qiu, J.H. & Lo, E.H. Ann. NY Acad. Sci. 1207, 50–57 (2010).
Arac, A. et al. Proc. Natl. Acad. Sci. USA 108, 13287–13292 (2011).
Iadecola, C., Zhang, F. & Xu, X. Am. J. Physiol. 268, R286–R292 (1995).
Kawano, T. et al. Nat. Med. 12, 225–229 (2006).
Gesuete, R. et al. Ann. Neurol. 66, 332–342 (2009).
Chen, J. et al. Antioxid. Redox Signal. published online, 10.1089/ars.2011.4298 (22 February 2012).
Albers, G.W. et al. Stroke 42, 2645–2650 (2011).
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Garcia-Bonilla, L., Iadecola, C. Peroxiredoxin sets the brain on fire after stroke. Nat Med 18, 858–859 (2012). https://doi.org/10.1038/nm.2797
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DOI: https://doi.org/10.1038/nm.2797
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