Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766–773).
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References
Herman, D.S. et al. N. Engl. J. Med. 366, 619–628 (2012).
Guo, W. et al. Nat. Med. 18, 766–773 (2012).
Brauch, K.M. et al. J. Am. Coll. Cardiol. 54, 930–941 (2009).
Greaser, M.L. et al. J. Mol. Cell. Cardiol. 44, 983–991 (2008).
Opitz, C.A., Leake, M.C., Makarenko, I., Benes, V. & Linke, W.A. Circ. Res. 94, 967–975 (2004).
Refaat, M.M. et al. Heart Rhythm 9, 390–396 (2012).
Taylor, M. et al. Circulation 124, 876–885 (2011).
Makarenko, I. et al. Circ. Res. 95, 708–716 (2004).
Kong, S.W. et al. Circ. Cardiovasc. Genet. 3, 138–146 (2010).
Wang, E.T. et al. Nature 456, 470–476 (2008).
Ding, J.H. et al. EMBO J. 23, 885–896 (2004).
Xu, X. et al. Cell 120, 59–72 (2005).
Macrae, C.A. & McKenna, W.J. J. Am. Coll. Cardiol. 54, 942–943 (2009).
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Linke, W., Bücker, S. King of hearts: a splicing factor rules cardiac proteins. Nat Med 18, 660–661 (2012). https://doi.org/10.1038/nm.2762
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DOI: https://doi.org/10.1038/nm.2762