Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

King of hearts: a splicing factor rules cardiac proteins

Nature Medicine volume 18, pages 660–661 (2012)Cite this article

Subjects

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766–773).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Loss-of-function mutations in the splicing factor RBM20 cause dilated cardiomyopathy via the pathological splicing of cardiac proteins.

References

  1. Herman, D.S. et al. N. Engl. J. Med. 366, 619–628 (2012).

    Article  CAS  Google Scholar 

  2. Guo, W. et al. Nat. Med. 18, 766–773 (2012).

    Article  CAS  Google Scholar 

  3. Brauch, K.M. et al. J. Am. Coll. Cardiol. 54, 930–941 (2009).

    Article  CAS  Google Scholar 

  4. Greaser, M.L. et al. J. Mol. Cell. Cardiol. 44, 983–991 (2008).

    Article  CAS  Google Scholar 

  5. Opitz, C.A., Leake, M.C., Makarenko, I., Benes, V. & Linke, W.A. Circ. Res. 94, 967–975 (2004).

    Article  CAS  Google Scholar 

  6. Refaat, M.M. et al. Heart Rhythm 9, 390–396 (2012).

    Article  Google Scholar 

  7. Taylor, M. et al. Circulation 124, 876–885 (2011).

    Article  Google Scholar 

  8. Makarenko, I. et al. Circ. Res. 95, 708–716 (2004).

    Article  CAS  Google Scholar 

  9. Kong, S.W. et al. Circ. Cardiovasc. Genet. 3, 138–146 (2010).

    Article  CAS  Google Scholar 

  10. Wang, E.T. et al. Nature 456, 470–476 (2008).

    Article  CAS  Google Scholar 

  11. Ding, J.H. et al. EMBO J. 23, 885–896 (2004).

    Article  CAS  Google Scholar 

  12. Xu, X. et al. Cell 120, 59–72 (2005).

    Article  CAS  Google Scholar 

  13. Macrae, C.A. & McKenna, W.J. J. Am. Coll. Cardiol. 54, 942–943 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wolfgang A. Linke and Sandra Bücker are at the Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.,

    Wolfgang A Linke & Sandra Bücker

Authors
  1. Wolfgang A Linke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sandra Bücker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wolfgang A Linke.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Linke, W., Bücker, S. King of hearts: a splicing factor rules cardiac proteins. Nat Med 18, 660–661 (2012). https://doi.org/10.1038/nm.2762

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2762

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing