Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Getting to the core of addiction: Hooking CB2 receptor into drug abuse?

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: In the NAcc, CB2 receptors may be expressed by resident neurons (GABA medium spiny neurons (MSN), GABA parvalbumin neurons or cholinergic neurons) or by neurons that project to the NAcc (glutamatergic neurons from cortex or hippocampus or dopaminergic neurons from the ventral tegmental area (VTA)).

References

  1. 1

    Xi, Z.-X. et al. Nat. Neurosci. 14, 1160–1166 (2011).

    CAS  Article  Google Scholar 

  2. 2

    Di Marzo, V., Bifulco, M. & De Petrocellis, L. Nat. Rev. Drug Discov. 3, 771–784 (2004).

    CAS  Article  Google Scholar 

  3. 3

    Howlett, A.-C. et al. Pharmacol. Rev. 54, 161–202 (2002).

    CAS  Article  Google Scholar 

  4. 4

    Matsuda, L.A. et al. Nature 346, 561–564 (1990).

    CAS  Article  Google Scholar 

  5. 5

    Mackie, K. J. Neuroendocrinol. 20, 10–14 (2008).

    CAS  Article  Google Scholar 

  6. 6

    Stella, N. Glia 58, 1017–1030 (2010).

    Article  Google Scholar 

  7. 7

    Munro, S., Thomas, K.L. & Abu-Shaar, M. Nature 365, 61–65 (1993).

    CAS  Article  Google Scholar 

  8. 8

    Gong, J.-P. et al. Brain Res. 1071, 10–23 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Atwood, B.-K. & Maki, K. Br. J. Pharmacol. 160, 467–479 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Van Sickle, M.D et al. Science 310, 329–332 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Lanciego, J.-L. et al. J. Psychopharmacol. 25, 97–104 (2011).

    CAS  Article  Google Scholar 

  12. 12

    Klein, T.W. et al. J. Leukoc. Biol. 74, 486–496 (2003).

    CAS  Article  Google Scholar 

  13. 13

    Gamaleddin, I. et al. PLoS ONE 7, e29900 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Tremblay, M.-È. et al. J. Neurosci. 31, 16064–16069 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Antonello Bonci.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Morales, M., Bonci, A. Getting to the core of addiction: Hooking CB2 receptor into drug abuse?. Nat Med 18, 504–505 (2012). https://doi.org/10.1038/nm.2722

Download citation

Further reading

Search

Quick links