Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Hypothalamic BDNF and obesity: found in translation

A recent study provides new insights into the central control of energy balance and obesity, showing that feeding behavior in mice can be modulated by local dendritic translation of a key protein in neuronal plasticity brain-derived neurotrophic factor (pages 564–571).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Increased BDNF translation in VMH dendrites may strengthen connections to D2 neurons from the nucleus accumbens, enhancing the satiety effects of these neurons.


  1. Olshansky, S.J. et al. N. Engl. J. Med. 352, 1138–1145 (2005).

    CAS  Article  Google Scholar 

  2. Yi, C.X., Scherer, T. & Tschop, M.H. Nat. Neurosci. 14, 806–808 (2011).

    CAS  Article  Google Scholar 

  3. Xu, B. et al. Nat. Neurosci. 6, 736–742 (2003).

    CAS  Article  Google Scholar 

  4. Unger, T.J., Calderon, G.A., Bradley, L.C., Sena-Esteves, M. & Rios, M. J. Neurosci. 27, 14265–14274 (2007).

    CAS  Article  Google Scholar 

  5. Bellinger, L.L. & Bernardis, L.L. Physiol. Behav. 76, 431–442 (2002).

    CAS  Article  Google Scholar 

  6. An, J.J. et al. Cell 134, 175–187 (2008).

    CAS  Article  Google Scholar 

  7. Liao, G.Y. et al. Nat. Med. 18, 564–571 (2012).

    CAS  Article  Google Scholar 

  8. Klöckener, T. et al. Nat. Neurosci. 14, 911–918 (2011).

    Article  Google Scholar 

  9. Domingos, A.I. et al. Nat. Neurosci. 14, 1562–1568 (2011).

    CAS  Article  Google Scholar 

  10. Millhouse, O.E. Brain Res. 55, 71–87 (1973).

    CAS  Article  Google Scholar 

  11. Lobo, M.K. et al. Science 330, 385–390 (2010).

    CAS  Article  Google Scholar 

  12. Pramyothin, P. & Khaodhiar, L. Curr. Opin. Endocrinol. Diabetes Obes. 17, 460–466 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Charles V Mobbs.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Schwartz, E., Mobbs, C. Hypothalamic BDNF and obesity: found in translation. Nat Med 18, 496–497 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing