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An unheard benefit of phosphodiesterase inhibition

Nature Medicine volume 18, pages 206–207 (2012)Cite this article

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Noise-induced hearing loss is caused primarily by damage to auditory hair cells; however, humans are unable to regenerate damaged hair cells, necessitating the development of new therapeutic strategies to protect auditory hair cells. A new study suggests that the use of phosphodiesterase 5 (PDE5) inhibitors may provide a protective therapeutic route for hearing loss (pages 252–259).

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Figure 1: PDE5 inhibition in the rodent inner ear provides protection against NIHL.

Katie Vicari

Change history

  • 08 February 2012

     In the version of this article initially published, vardenafil was incorrectly referred to as Cialis. The reference to Cialis has now been deleted in the text, and the title has been amended to 'An unheard benefit of phosphodiesterase inhibition'. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Wanda Layman and Jian Zuo are at the Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.,

    Wanda Layman & Jian Zuo

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  1. Wanda Layman
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  2. Jian Zuo
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Correspondence to Jian Zuo.

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Layman, W., Zuo, J. An unheard benefit of phosphodiesterase inhibition. Nat Med 18, 206–207 (2012). https://doi.org/10.1038/nm.2647

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