The beneficial cytoprotective effects of heme oxygenase-1 (HO-1) in malaria infection are counterpoised by higher susceptibility to nontyphoidal Salmonella (NTS) bacteremia. A new study in mice co-infected with malaria and Salmonella provides a mechanism for the long-recognized association between malaria and NTS infection in African children.
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Katie Vicari
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C.A.M. is an employee of the Novatis Vaccines Institute for Global Health and the recipient of a clinical research fellowship from GlaxoSmithKline.
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MacLennan, C. Host defense against malaria favors Salmonella. Nat Med 18, 21–22 (2012). https://doi.org/10.1038/nm.2636
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DOI: https://doi.org/10.1038/nm.2636
