Commentary | Published:

Re-establishing immunological self-tolerance in autoimmune disease

Nature Medicine volume 18, pages 5458 (2012) | Download Citation

  • An Erratum to this article was published on 05 April 2012

This article has been updated

Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individuals with autoimmune disease.

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Change history

  • 05 April 2012

     In the version of this article initially published, the affiliation of one author (R.M.R.) was incorrectly listed. The correct affiliation is Lerner Research Institute and Mellen Center for Multiple Sclerosis Treatment and Research (Neurological Institute). The error has been corrected in the HTML and PDF versions of the article.

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Author information

Affiliations

  1. Shimon Sakaguchi is at the Laboratory of Experimental Immunology, World Premier Initiative Immunology Frontier Research Center, Osaka University, Suita, Japan, and the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

    • Shimon Sakaguchi
  2. Fiona Powrie is at the Sir William Dunn School of Pathology at the University of Oxford, Oxford, UK and the Translational Gastroenterology Unit, Experimental Medicine Division–Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

    • Fiona Powrie
  3. Richard M. Ransohoff is at the Neuroinflammation Research Center, Lerner Research Institute and Mellen Center for Multiple Sclerosis Treatment and Research (Neurological Institute), Cleveland Clinic, Cleveland, Ohio, USA.

    • Richard M Ransohoff

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Shimon Sakaguchi.

About this article

Publication history

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DOI

https://doi.org/10.1038/nm.2622

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