Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Fruitful progress to fertility: Male fertility in the test tube

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Standard and experimental options for preserving male fertility.

Marina Corral


  1. Moragianni, V.A. & Penzias, A.S. Curr. Opin. Obstet. Gynecol. 22, 189–192 (2010).

    Article  Google Scholar 

  2. Woodruff, T.K. Nat. Rev. Clin. Oncol. 7, 466–475 (2010).

    Article  Google Scholar 

  3. Wyns, C. et al. Hum. Reprod. 26, 737–747 (2011).

    CAS  Article  Google Scholar 

  4. Wu, X. et al. Proc. Natl. Acad. Sci. USA 106, 21672–21677 (2009).

    CAS  Article  Google Scholar 

  5. Hermann, B.P. et al. Hum. Reprod. published online, 10.1093/humrep/der343 (20 October 2011).

  6. Kanatsu-Shinohara, M. et al. Biol. Reprod. 69, 612–616 (2003).

    CAS  Article  Google Scholar 

  7. Kubota, H., Avarbock, M.R. & Brinster, R.L. Proc. Natl. Acad. Sci. USA 101, 16489–16494 (2004).

    CAS  Article  Google Scholar 

  8. Richardson, T.E., Chapman, K.M., Tenenhaus Dann, C., Hammer, R.E. & Hamra, F.K. PLoS ONE 4, e6308 (2009).

    Article  Google Scholar 

  9. Sadri-Ardekani, H., Akhondi, M.A., van der Veen, F., Repping, S. & van Pelt, A.M.M. J. Am. Med. Assoc. 305, 2416–2418 (2011).

    CAS  Article  Google Scholar 

  10. Hermann, B.P. et al. Stem Cells 25, 2330–2338 (2007).

    CAS  Article  Google Scholar 

  11. Sato, T. et al. Nature 471, 504–507 (2011).

    CAS  Article  Google Scholar 

  12. Trowell, O.A. Exp. Cell Res. 16, 118–147 (1959).

    CAS  Article  Google Scholar 

  13. Kee, K., Angeles, V.T., Flores, M., Nguyen, H.N. & Reijo Pera, R.A. Nature 462, 222–225 (2009).

    CAS  Article  Google Scholar 

  14. Park, T.S. et al. Stem Cells 27, 783–795 (2009).

    CAS  Article  Google Scholar 

  15. Panula, S. et al. Hum. Mol. Genet. 20, 752–762 (2011).

    CAS  Article  Google Scholar 

  16. Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M. Cell 146, 519–532 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kyle E Orwig.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Clark, A., Phillips, B. & Orwig, K. Fruitful progress to fertility: Male fertility in the test tube. Nat Med 17, 1564–1565 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer