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A sweet T cell response

Nature Medicine volume 17, pages 15511552 (2011) | Download Citation

Although protein-polysaccharide conjugate vaccines provide notable clinical benefits, it is still not fully understood how they work. A new mechanism of action for these vaccines has been identified in which T cells can recognize sugar epitopes in the context of the major histocompatibility complex (MHC) provided they are bound to a protein 'anchor', which allows binding of the sugar epitope to the MHC (pages 1602–1609).

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Author information

Affiliations

  1. Rino Rappuoli and Ennio De Gregorio are at Novartis Vaccines and Diagnostics, Siena, Italy.

    • Rino Rappuoli
    •  & Ennio De Gregorio

Authors

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Competing interests

R.R. and E.D.G. are employed by Novartis Vaccines. They have collaborated with D. Kasper on GBS vaccines.

Corresponding author

Correspondence to Rino Rappuoli.

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DOI

https://doi.org/10.1038/nm.2587

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