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NF-κB in DCs: it takes effort to be immature

The nuclear factor-κB (NF-κB) family of regulators is well known for mediating dendritic cell (DC) maturation—that is, the acquisition of the functions required for full activation of T cells. Paradoxically, a key member of this family, NF-κB1, is now also implicated in maintaining DCs in an immature state (pages 1663–1667).

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Figure 1: The roles of the NF-κB family in the regulation of DC maturation.

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Correspondence to Rémi J Creusot.

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Creusot, R. NF-κB in DCs: it takes effort to be immature. Nat Med 17, 1554–1556 (2011). https://doi.org/10.1038/nm.2586

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