A new study suggests that regulation of the serum- and glucocorticoid-regulated kinase (SGK1) is important for ensuring uterine receptivity and maintenance of pregnancy (pages 1509–1513). Additional work will be required to determine whether SGK1 could be potentially targeted to treat infertility and prevent miscarriage and whether it can be used as a biomarker.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion
Reproductive Sciences Open Access 06 June 2023
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Aghajanova, L., Hamilton, A.E. & Giudice, L.C. Semin. Cell Dev. Biol. 19, 204–211 (2008).
Cakmak, H. & Taylor, H.S. Hum. Reprod. Update 17, 242–253 (2011).
Lessey, B.A. Fertil. Steril. 96, 522–529 (2011).
Haas, D.M. & Ramsey, P.S. Cochrane Database Syst. Rev. 10.1002/14651858.CD003511.pub2 (8 July 2009).
Dey, S.K. J. Clin. Invest. 120, 952–955 (2010).
Stewart, C.L. et al. Nature 359, 76–79 (1992).
Salker, M.S. et al. Nat. Med. 17, 1509–1513 (2011).
Lang, F. et al. Physiol. Rev. 86, 1151–1178 (2006).
Feroze-Zaidi, F. et al. Endocrinology 148, 5020–5029 (2007).
Lim, H.J. & Wang, H. J. Clin. Invest. 120, 1004–1015 (2010).
Lang, F., Perrotti, N. & Stournaras, C. Int. J. Biochem. Cell Biol. 42, 1571–1575 (2010).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Fisher, S., Giudice, L. SGK1: a fine balancing act for human pregnancy. Nat Med 17, 1348–1349 (2011). https://doi.org/10.1038/nm.2549
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2549