Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Turning up the heat on colorectal cancer

Mutations in the microsatellite of the chaperone heat shock protein 110 (HSP110) yield a mutant protein that counteracts oncogenic potential, enhances responsiveness to chemotherapy and associates with increased survival in individuals with colorectal cancers that arise through defective DNA mismatch repair (pages 1283–1289).

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Model for the interaction of HSP110 and HSP110ΔE9 in colorectal cancers.

Marina Corral


  1. Boland, C.R. & Goel, A. Gastroenterology 138, 2073–2087 (2010).

    Article  CAS  Google Scholar 

  2. Ribic, C.M. et al. N. Engl. J. Med. 349, 247–257 (2003).

    Article  CAS  Google Scholar 

  3. Sargent, D.J. et al. J. Clin. Oncol. 28, 3219–3226 (2010).

    Article  CAS  Google Scholar 

  4. Popat, S., Hubner, R. & Houlston, R.S. J. Clin. Oncol. 23, 609–618 (2005).

    Article  CAS  Google Scholar 

  5. Sinicrope, F.A. et al. J. Natl. Cancer Inst. 103, 863–875 (2011).

    Article  CAS  Google Scholar 

  6. Elsaleh, H. et al. Lancet 355, 1745–1750 (2000).

    Article  CAS  Google Scholar 

  7. Tejpar, S., Saridaki, Z., Delorenzi, M., Bosman, F. & Roth, A.D. J. Natl. Cancer Inst. 103, 841–844 (2011).

    Article  Google Scholar 

  8. Dorard, C. et al. Nat. Med. 17, 1283–1289 (2011).

    Article  CAS  Google Scholar 

  9. Khalil, A.A., Kabapy, N.F., Deraz, S.F. & Smith, C. Biochim. Biophys. Acta 1816, 89–104 (2011).

    CAS  PubMed  Google Scholar 

  10. Slaby, O. et al. Oncol. Rep. 21, 1235–1241 (2009).

    Article  CAS  Google Scholar 

  11. Markowitz, S. et al. Science 268, 1336–1338 (1995).

    Article  CAS  Google Scholar 

  12. Rampino, N. et al. Science 275, 967–969 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Andrew T Chan.

Ethics declarations

Competing interests

A.T.C. has served as a consult to Bayer HealthCare and Millennium Pharmaceuticals.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chan, A. Turning up the heat on colorectal cancer. Nat Med 17, 1186–1188 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing