IDO participates in immunosuppression by virtue of its enzymatic activity in tryptophan metabolism. These authors now show it induces tolerance through a separate mechanism by acting as a signaling protein in response to transforming growth factor-β.
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Swami, M. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Med 17, 1059 (2011). https://doi.org/10.1038/nm.2485
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DOI: https://doi.org/10.1038/nm.2485
