Alter, G. et al. Nature 476, 96–100.
The authors show that natural killer (NK) cells can mediate immune pressure on HIV-1 in vivo in humans. The virus can evolve to evade this immune mechanism by selecting for alternative sequence polymorphisms that favor binding to inhibitory killer-cell immunoglobulin-like receptors on NK cells.
Rights and permissions
About this article
Cite this article
Swami, M. HIV-1 adaptation to NK-cell-mediated immune pressure. Nat Med 17, 1059 (2011). https://doi.org/10.1038/nm.2481
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2481
This article is cited by
-
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes
Acta Pharmacologica Sinica (2024)
