Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Paraoxonase-1 and clopidogrel efficacy

Nature Medicine volume 17, pages 1040–1041 (2011)Cite this article

Subjects

To the Editor:

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bioactivation of clopidogrel (CLO) and formation of different thiol isomers by esterase- and CYP-catalyzed metabolism of 2-oxo-clopidogrel.
Figure 2: HPLC profiles of incubations of 2-oxo-clopidogrel with or without NADPH.

References

  1. Pereillo, J.M. et al. Drug Metab. Dispos. 30, 1288–1295 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Dansette, P.M., Libraire, J., Bertho, G. & Mansuy, D. Chem. Res. Toxicol. 22, 369–373 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Kazui, M. et al. Drug Metab. Dispos. 38, 92–99 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Sibbing, D. et al. Eur. Heart J. 32, 1605–1613 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Bouman, H.J. et al. Nat. Med. 17, 110–116 (2011).

    Article  CAS  Google Scholar 

  6. Tuffal, G. et al. Thromb. Haemost. 105, 696–705 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Takahashi, M., Pang, H., Kawabata, K., Farid, N.A. & Kurihara, A. J. Pharm. Biomed. Anal. 48, 1219–1224 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Billecke, S. et al. Drug Metab. Dispos. 28, 1335–1342 (2000).

    CAS  PubMed  Google Scholar 

  9. Correia, M.A. & Ortiz de Montellano, P.R. in Cytochrome P450 Structure, Mechanism, and Biochemistry 3rd edn. (ed. Ortiz de Montellano, P.R.) 247–295 (Kluwer Academic/Plenum Publishers, New York, 2005).

    Book  Google Scholar 

  10. Mansuy, D. & Dansette, P.M. Arch. Biochem. Biophys. 507, 174–185 (2011).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank F. Hurbin and S. Roy (Sanofi-Aventis, France) for a gift of authentic derivatives of the endo- and cis-thiols6.

Author information

Authors and Affiliations

  1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8601, Université Paris Descartes, Paris, France

    Patrick M Dansette, Julien Rosi, Gildas Bertho & Daniel Mansuy

Authors
  1. Patrick M Dansette
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julien Rosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gildas Bertho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel Mansuy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Patrick M Dansette.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Methods and Supplementary Figure 1 (PDF 153 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dansette, P., Rosi, J., Bertho, G. et al. Paraoxonase-1 and clopidogrel efficacy. Nat Med 17, 1040–1041 (2011). https://doi.org/10.1038/nm.2436

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2436

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing