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Paraoxonase-1 and clopidogrel efficacy

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Figure 1: Bioactivation of clopidogrel (CLO) and formation of different thiol isomers by esterase- and CYP-catalyzed metabolism of 2-oxo-clopidogrel.
Figure 2: HPLC profiles of incubations of 2-oxo-clopidogrel with or without NADPH.


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We thank F. Hurbin and S. Roy (Sanofi-Aventis, France) for a gift of authentic derivatives of the endo- and cis-thiols6.

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Correspondence to Patrick M Dansette.

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Dansette, P., Rosi, J., Bertho, G. et al. Paraoxonase-1 and clopidogrel efficacy. Nat Med 17, 1040–1041 (2011).

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