Certain human leukocyte antigen (HLA) alleles are associated with vigorous human immunodeficiency virus (HIV)-specific CD8+ T cell responses and good clinical outcomes. A new study suggests that CD8+ T cell–mediated killing of regulatory CD4+ T cells may partially explain how people with these protective alleles control HIV-1 replication (pages 989–995).
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Blankson, J. Killing the messenger to maintain control of HIV. Nat Med 17, 927–928 (2011). https://doi.org/10.1038/nm.2427
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DOI: https://doi.org/10.1038/nm.2427
