To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell–derived IL-10 plays a key role in controlling autoimmunity.
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Supported by grants from the Medical Research Council UK and the Wellcome Trust and by the Wellcome Trust (D.G.) and Medical Research Council (S. M. A).
The authors declare no competing financial interests.
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Fillatreau, S., Sweenie, C., McGeachy, M. et al. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 3, 944–950 (2002). https://doi.org/10.1038/ni833
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