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B cell memory: how to start and when to end

Antigen-driven selection in germinal centers lays the foundation of effective B cell memory. Two reports in this issue reveal novel mechanisms that control effective formation of germinal centers and their long-term persistence in vivo.

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Figure 1: Stepwise helper T cell–regulated development of memory B cells.

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Correspondence to Michael G McHeyzer-Williams.

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Pelletier, N., McHeyzer-Williams, M. B cell memory: how to start and when to end. Nat Immunol 10, 1233–1235 (2009). https://doi.org/10.1038/ni1209-1233

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