Nucleotide-binding oligomerization domain 2 (Nod2) is required for sensing of intracellular bacteria and subsequent inflammatory responses. Unexpectedly, new evidence suggests that Nod2 influences T helper cell signaling, proliferation and differentiation and effector responses against Toxoplasma gondii.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gelman, A.E. et al. Immunity 25, 783–793 (2006).
Zhao, Y. et al. J. Immunol. 182, 6278–6286 (2009).
Shaw, M.H. et al. Nat. Immunol. 10, 1267–1274 (2009).
Chen, G., Shaw, M.H., Kim, Y.G. & Nunez, G. Annu. Rev. Pathol. 4, 365–398 (2009).
Villegas, E.N., Lieberman, L.A., Carding, S.R. & Hunter, C.A. Infect. Immun. 70, 4757–4761 (2002).
Hall, H.T. et al. Eur. J. Immunol. 38, 64–72 (2008).
Ghosh, P., Tan, T.H., Rice, N.R., Sica, A. & Young, H.A. Proc. Natl. Acad. Sci. USA 90, 1696–1700 (1993).
Zheng, Y., Vig, M., Lyons, J., Van Parijs, L. & Beg, A.A. J. Exp. Med. 197, 861–874 (2003).
Sánchez-Valdepeñas, C., Martin, A.G., Ramakrishnan, P., Wallach, D. & Fresno, M. J. Immunol. 176, 4666–4674 (2006).
Ishimaru, N., Kishimoto, H., Hayashi, Y. & Sprent, J. Nat. Immunol. 7, 763–772 (2006).
Vallabhapurapu, S. et al. Nat. Immunol. 9, 1364–1370 (2008).
Reichmann, G., Villegas, E.N., Craig, L., Peach, R. & Hunter, C.A. J. Immunol. 163, 3354–3362 (1999).
Penack, O. et al. J. Exp. Med. 206, 2101–2110 (2009).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Salek-Ardakani, S., Croft, M. T cells need Nod too?. Nat Immunol 10, 1231–1233 (2009). https://doi.org/10.1038/ni1209-1231
Issue Date:
DOI: https://doi.org/10.1038/ni1209-1231