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Alternative lifestyles of T cells

T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.

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Figure 1: Functional plasticity of T cells: the cytokine environment controls the lineage conversion of a T helper subset.

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Tato, C., Cua, D. Alternative lifestyles of T cells. Nat Immunol 9, 1323–1325 (2008). https://doi.org/10.1038/ni1208-1323

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