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PYHIN proteins: center stage in DNA sensing

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Innate immune responses to pathogens are often triggered by nucleic acids, including DNA delivered to the cytoplasm of cells. IFI16 is a newly identified cytoplasmic DNA sensor that induces the transcription of genes involved in the innate response.

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Figure 1: The PYHIN proteins IFI16 and p204 detect cytosolic DNA, which leads to the induction of type I interferon.

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Correspondence to Caetano Reis e Sousa.

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Goubau, D., Rehwinkel, J. & Reis e Sousa, C. PYHIN proteins: center stage in DNA sensing. Nat Immunol 11, 984–986 (2010). https://doi.org/10.1038/ni1110-984

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