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PYHIN proteins: center stage in DNA sensing


Innate immune responses to pathogens are often triggered by nucleic acids, including DNA delivered to the cytoplasm of cells. IFI16 is a newly identified cytoplasmic DNA sensor that induces the transcription of genes involved in the innate response.

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Figure 1: The PYHIN proteins IFI16 and p204 detect cytosolic DNA, which leads to the induction of type I interferon.


  1. 1

    Takeuchi, O. & Akira, S. Cell 140, 805–820 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Unterholzner, L. et al. Nat. Immunol. 11, 997–1004 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Hornung, V. & Latz, E. Nat. Rev. Immunol. 10, 123–130 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Takaoka, A. et al. Nature 448, 501–505 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Ablasser, A. et al. Nat. Immunol. 10, 1065–1072 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Chiu, Y.H., Macmillan, J.B. & Chen, Z.J. Cell 138, 576–591 (2009).

    CAS  Article  Google Scholar 

  7. 7

    Wang, Z. et al. Proc. Natl. Acad. Sci. USA 105, 5477–5482 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Ishii, K.J. et al. Nature 451, 725–729 (2008).

    CAS  Article  Google Scholar 

  9. 9

    Lippmann, J. et al. Cell. Microbiol. 10, 2579–2588 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Yang, P. et al. Nat. Immunol. 11, 487–494 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Ludlow, L.E., Johnstone, R.W. & Clarke, C.J. Exp. Cell Res. 308, 1–17 (2005).

    CAS  Article  Google Scholar 

  12. 12

    Hornung, V. et al. Nature 458, 514–518 (2009).

    CAS  Article  Google Scholar 

  13. 13

    Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J. & Alnemri, E.S. Nature 458, 509–513 (2009).

    CAS  Article  Google Scholar 

  14. 14

    Burckstummer, T. et al. Nat. Immunol. 10, 266–272 (2009).

    Article  Google Scholar 

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Correspondence to Caetano Reis e Sousa.

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Goubau, D., Rehwinkel, J. & Reis e Sousa, C. PYHIN proteins: center stage in DNA sensing. Nat Immunol 11, 984–986 (2010).

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