Peptides able to positively select major histocompatibility complex class II–restricted thymocytes have not yet been defined. Two new reports identify and ascribe important extrathymic functions to several positively selecting peptides for CD4+ T cells.
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Wucherpfennig, K., Gagnon, E. Positively selecting peptides: their job does not end in the thymus. Nat Immunol 10, 1143–1144 (2009). https://doi.org/10.1038/ni1109-1143
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DOI: https://doi.org/10.1038/ni1109-1143
